Ferrous +C Chewable Product Information

INTRODUCING FERRIC PYROPHOSPHATE  

Ferric Pyrophosphate is different. Ferric Pyrophosphate exists as a complex of the ferric  (Fe3+) cation, bound strongly by the pyrophosphate species1. Ferric pyrophosphate iron  replacement preparations contain approximately 12% EI2 and are administered both orally and  intravenously3.  

FERRIC PYROPHOSPHATE – BENEFITS  

The tightly complexed ferric pyrophosphate iron is a form less soluble in gastric acid4,  and thus is gentle on the stomach and gastrointestinal tract. All forms of dietary iron are  predominantly absorbed while transiting through the duodenum and proximal jejunum, and in  order to be absorbed by the intestinal lumen cells, iron must first be converted from the stable  ferric state to the ferrous state, or be protein bound. This conversion of ferric to ferrous iron  is facilitated by other dietary components such as ascorbic acid (Vitamin C) which act as a  reducing agent(5), enhancing iron absorption.  

Being poorly soluble at a low pH, Ferric pyrophosphate has a slower absorption rate while  transiting the intestines, and so poses an exciting therapeutic option with higher iron  bioavailability3.  

IS BIOAVAILABILITY IMPORTANT?  

Improving bioavailability and absorption of the iron in a supplement helps to minimise  potential gastrointestinal side-effects since unabsorbed iron is the likely cause gut  inflammation and dysbiosis, and enhanced growth of enteropathogens(6).  

Iron supplementation with a formulation containing ferric pyrophosphate as an active  ingredient can help maintain healthy iron levels, with a milder gastrointestinal effect(3).  

FORMULATION 

Ferric Pyrophosphate 80mg Equivalent to Iron 20mg Ascorbic Acid 70mg

DOSAGE SUMMARY 

Adults and Children 14+ Chew one tablet daily. 

For optimal Absorption take  on an empty stomach.  

Children 4-13 years  Tablet has a score mark which  allows the tablet to be halved.  Chew 1/2 tablet per day. 

REFERENCES 

1. Gupta A, Amin NB, Besarab A, Vogel SE, Divine GW, Yee J, Anandan JV. Dialysate iron therapy: infusion of  soluble ferric pyrophosphate via the dialysate during hemodialysis. Kidney Int. 1999 May;55(5):1891-8.  2. Drugs.com [internet] Ferric Pyrophosphate; Copyright; Last updated on Dec 5, 2021; March 2022].  3. Drugbank [internet] Available at https://go.drugbank.com/drugs/DB09147 [Accessed March 2022]  4. Sabatier, M Impact of Ascorbic Acid on the In Vitro Iron Bioavailability of a Casein-Based Iron Fortificant  Nutrients 2020, 12, 2776.  

5. Sharp P, Srai SK. Molecular mechanisms involved in intestinal iron absorption. World J Gastroenterol.  2007;13(35):4716-4724.